Staff Bibliographies

Changqing Kao, PhD, Director of Deep Brain Stimulation (DBS) Services, joined Sentient Medical Systems in 2001. He received his MD from Bethune Medical College in Changchun, China and his PhD in Neurophysiology from the Virginia Commonwealth University. Dr. Kao has supervised over 400 DBS cases. He received the Chancellor's Research Award from Vanderbilt University in 2006 and the American Society for Neurophysiological Monitoring Research Prize (jointly) in 2008.

 

PEER REVIEWED PUBLICATIONS

  1. Kao CC. Master theses: Morphine analgesia and acupuncture in the lateral habenular nucleus. Norman Bethune University of Medical Sciences Library, 1983.

  2. Kao CC, Shao W. The role of forebrain-habenula nucleus raphe magnus system in acupuncture analgesia. The Second National Symposium on Acupuncture and Moxibustion and Acupuncture Anesthesia, Beijing, 1984.

  3. Kao CC, Shao W. Effect of nucleus accumbens on pain-discharges of parafascicular nucleus in rat. Acupuncture Research. 1984; 9(4): 313-16.

  4. Kao CC, Shao W. Effects on discharging from lateral habenula nucleus by naloxone micro injection into nucleus accumbens. Journal of Bethune University of Medical Sciences. 1985; (11)1: 42-6.

  5. Kao CC, Shao W. Effect of stimulation of nucleus accumbens and naloxone micro injection on nociceptive unit discharges in the lateral habenula nucleus. Acta Physiologica Sinica. 1985; 37(1): 24-30.

  6. McHaffie JG, Kao CC, Stein BE. Nociceptive neurons in the rat superior colliculus: Response properties, topography and functional implications. Journal of Neurophysiology. 1989; 62(2): 510-25.

  7. Kao CC, McHaffie JG, Stein BE. Multiple overlapping sensory and motor maps. In: Stein BE, Alex MA, eds. The Merging of the Senses. Cambridge: A Bradford Book, The MIT Press. 1993; 94-5.

  8. Kao CC. Dissertation: Visual developoment of superior colliculus. Virginia Commonwealth University Library, 1994.

  9. Kao CC, McHaffie JG, Meredith MA, Stein BE. Functional Development of a central visual map in cat. J. Neurophysiology. 1994; 72(1): 266-72.

  10. Gibbs JW, III, Zhang Y, Kao CC, Holloway KL, Oh K, Coulter DA. Characterization of GABAA receptors function in human temporal cortical neurons. J. Neurophysiology. 1996; 75(4).

  11. Kao CC, Coulter DA. Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in-vitro. J Neurophysiology. 1997; 77: 2661-76.

  12. Reeves TM, Kao CC, Phillips LL, Povlishock JT. Presynaptic excitability changes following traumatic brain injury in the rat. J Neuroscience Res. 2000; 60: 370-9.

  13. Dawant BM, Li R, Cetinkaya E, Kao CC, Fitzpatrick JM, Konrad PE. Computerized atlas-guided positioning of deep brain stimulators: A feasibility study, Lecture Notes in Computer Science (LNCS) 2717. In: Gee JC, Maintz JB, Vannier MW, eds. Proceedings of the Second International Workshop on Biomedical Image Registrationnier. 2003; 142-150.

  14. Davis TL, Charles D, Kao CC, Fang J, Fenichel GM, Konrad PE. The anatomic specificity of rest tremor suppression. Movement Disorders. 2004; 19(9): s319.

  15. Kao CC, Charles D, Davis T, Fang J, Albea J, Konrad PE. Asymmetry of overactivity between left and right subthalamic nucleus parallels severity of extremity symptoms in Parkinson's disease patients. Movement Disorders. 2004; 19(9): s220.

  16. Kao CC, Goforth PB, Ellis EF, Satin LS. Potentiation of GABA(A) currents after mechanical injury of cortical neurons. J Neurotrauma. 2004; 21(3): 259-70.

  17. Wells J, Konrad PE, Kao CC, Mahadevan-Jansen A, Jansen ED. A comparative study of the methodology and recorded potentials elicited from nerves stimulated with pulsed laser versus standard electrical energy. (In preparation for submission to Journal of Biomedical Optics, 2005.)

  18. D'Haese PF, Cetinkaya E, Konrad PE, Kao CC, Dawant BM. Computer-aided placement of deep brain stimulators: From planning to intraoperative guidance. IEEE Transaction on Medical Imaging. 2005; 24(11): 1469-78.

  19. Wells J, Kao CC, Jansen ED, Konrad PE, Mahadevan-Jansen A. Application of infrared light for in vivo neural stimulation. Journal of Biomedical Optics, 2005, accepted.

  20. Fitzpatrick JM, Konrad PE, Nickele C, Cetinkaya E, Kao CC. Accuracy of customized miniature stereotactic platforms. Stereotactic and Functional Neurosurgery. 2005; 83(1): 25-31.

  21. Wells J, Kao CC, Mariappan K, Albea J, Jansen ED, Konrad PE, Mahadevan-Jansen A. Optical stimulation of neural tissue in vivo. Optics Letters. 2005; 30(5): 504-6.

  22. Wells J, Kao CC, Jansen ED, Konrad PE, Mahadevan-Jansen A. Application of infrared light for in vivo neural simulation. Journal of Biomedical Optics. 2005; 10(6): 64003-11.

  23. Wells J, Mahadevan-Jansen A, Bendett M, Webb J, Ralph H, Kao CC, Konrad PE, Jansen ED. Lasers stimulate new techniques in nerve studies. Biophotonics International. 2006; 13(10): 30-2.

  24. Wells J, Konrad PE, Kao CC, Jansen ED, Mahadevan-Jansen A. Pulsed laser versus electrical energy for peripheral nerve stimulation. Journal Neural Modulation, submitted April, 2006.

  25. Wells J, Konrad PE, Kao CC, Jansen ED, Mahadevan-Jansen A. Stimulating nerves with laser precision. SPIE, submitted April, 2006.

  26. Spooner J, Yu H, Kao CC, Sillay K, Konrad PE. Neuromodulation of the cingulum for neuropathic pain after spinal cord injury. Journal of Neurosurgery. 2007; 107: 169-72.

  27. Wells J, Kao CC, Konrad PE, Milner T, Kim J, Mahadevan-Jansen A, Jansen ED. Biophysical mechanisms of transient optical stimulation of peripheral nerve. Biophysical J. 2007; 93: 2567-80.

  28. Pallavaram S, Yu H, D'Haese P, Spooner J, Koyama T, Bodenheimer B, Kao CC, Konrad PE, Dawant, BM. Automated selection of anterior and posterior commissures based on a deformable atlas and its evaluation based on manual selections by neurosurgeons. SPIE, 2007, accepted.

  29. D'Haese P, Yu H, Pallavaram S, Kao CC, Konrad PE, Dawant BM. Computer-aided programming of deep brain stimulation for the treatment of movement disorders. SPIE, 2007, accepted.

  30. Feng H, Mathews G, Kao CC, MacDonald R. Alteration of BABA receptor function and allosteric modulatio during development of status epileptics. J Neurophysiology. 2007; R2 in press.

  31. Kao CC, Carron R, Louis A, Konrad PE. Recovering effects of thalamocortical stimulation on ischemia-induced inactivation of cortical oscillation in rat brain slices. Paper preparation (manuscript preparation).

  32. Feng H, Mathews G, Kao CC, MacDonald RL. Seizure stage-dependent alterations of GABA receptor phasic inhibitiion and allosteric modulation during development of status epilepticus. J Neurophysiology, submitted.

  33. Kao CC, Spooner J, Charles D, Davis T, Fang JY, Albea J, Konrad PE. Asymmetry of simultaneious subthalamic nucleus recordings parallels severity of extremity symptoms in parkinson's disease patients. Movement Disorders (manuscript ready for submission).

 

ABSTRACTS:

  1. Kao CC, McHaffie JG, Stein BE. Response properties and organization of nociceptive neurons in the rat superior colliculus. Society for Neuroscience Abstract. 1987; 13: 986.

  2. Kao CC, McHaffie JG, Stein BE. Response properties and somatotopy of vibrissa-activated neurons in rat superior colliculus. Socity for Neuroscience Abstract. 1989; 15: 388.

  3. Kao CC, McHaffie JG, Meredith MA, Clemo HR, Stein BE. Comparative magnification of the vibrissa representatoin in the superior colliculus of rodents and cats. Society for Neuroscience Abstract. 1990; 16: 223.

  4. Kao CC, McHaffie JG, Meredith MA, Stein BE. Physiological maturation of the visual topography in the cat superior colliculus. Society for Neuroscience Abstract. 1991; 17: 1378.

  5. Redgrave P, Simkins M, McHaffie JG, Kao CC, Goldberg SJ, Stein BE. The role of nociceptive superior colliculus neurons in approach behaviors. Society for Neuroscience Abstract. 1993; 19: 1407.

  6. Kao CC, Stein BE, Coulter DA. Postnatal development of synaptic responses in deep layers of superior colliculus slices studied using whole cell patch techniques. Society for Neuroscience Abstract. 1993; 19: 768.

  7. Stein BE, Redgrave P, Kao CC, McHaffie JG. Nociceptive neurons in the superior colliculus and their role in approach and withdrawal behaviors. 7th World Congress on Pain Abstracts. 1993; 258.

  8. Kao CC. Visual development of superior colliculus. Presentation in Department of Physiology, May 1994.

  9. Kao CC, Stein BE, Coulter DA. Postnatal development of excitatory synaptic function in deep layers of superior colliculus. Society for Neuroscience Abstract. 1994; 20: 1186.

  10. Kao CC, Coulter DA. Characterization of the corticothalamic excitatory synaptic potential in thalamic neurons. Society for Neuroscience Abstract. 1995; 21: 113.

  11. Kao CC, Coulter DA. Local inhibitory responses in thalamocortical relay neurons: Comparison of rat and guinea pig in vitro. Society for Neuroscience Abstract. 1996; 22: 104.

  12. Kao CC, Povlishock JT, Phillips LL, Reeves TM. Presynaptic excitability increases following traumatic brain injury. 16th Annual National Neurotrauma Society Meeting, 1998.

  13. Kao CC. Neurotrauma effects on thalamocortical activity: Suppression of slow cortical oscillation. Neurotrauma Seminar Presentation Slide Talk, 1999.

  14. Reeves TM, Kao CC, Povlishock JT, BUllock MR. COmbined electrophysiological recording and microdialysis in severe human head injury. National Neurotrauma Society Abstract, J Neurotrauma. 1999; 16: 971.

  15. Zhu J, Kao CC, Povlishock JT, Phillips LL, Bullock MR, Reeves TM. Endogenous lactate acid sustain evoked synaptic responses in vitro hippocampal slice during glucose deprivation. National Neurotrauma Society Meeting, 1999.

  16. Kao CC, Zhu J, Povlishock JT, Phillips LL, Reeves TM, Bullock MR. Lactate as a postinjury metabolic substrate in spontaneous cortical oscillation. National Neurotrauma Society Abstract, J Neurotrauma. 1999; 16: 991.

  17. Kao CC, Povlishock JT, Reeves TM. Suppression of slow cortical oscillation recorded in vitro following traumatic brain injury in adult rats. Society for Neuroscience Abstract, 1999.

  18. Kao CC, Goforth PB, Ellis EF, Satin LS. Mechanical injury-induced enhancement of GABAa currents in cortical neurons. Society for Neuroscience Abstract, 2000.

  19. Kao CC, Goforth PB, Ellis EF, Satin LS. Mechanical injury-induced enhancement of GABAa function in cortical neurons and implications for clinical TBI-induced coma. National Neurotrauma Society Abstract, 2000.

  20. Konrad PE, Kao CC. Treatment of diffuse central neuropathic pain through the use of cingulum neuromodulation. International Symposium of Neuromodulatin- Defining the Future, Cleveland, 2001.

  21. Shieh C, Kao CC, Konrad PE. Strenght-duration curve and chronaxie for essential tremor patients with DBS implants. 7th National Parkinson Foundation International Symposium on Parkinson's Disease Research. San Diego, 2001.

  22. Kao CC, Konrad P, Davis T, Zhang J. Minimal tissue reaction to thalamic lead implantation for tremor: A 22-month post-mortem study. Annual Meeting of American Assocation of Neurological Surgeons, 2002.

  23. Konrad PE, Kao CC, Davis T, Shieh C. Evidence for strength-duration curve in humans undergoing thalamic stimulation for tremor control. Annual Meeting of American Association of Neurlogical Sugeons, 2002.

  24. Konrad PE, Franck J, Song J, Kao CC, Franklin R, Haer F. Microframe-based deep brain stimulation utilizing StarFix: Experience from Vanderbilt University and St. Mary's Regionsl Medical Centers. Neuromodulation 2002: Defining the Future, Aix-Les-Bains, 2002.

  25. Kao CC, Albea J, Konrad PE. Asymmetry of hyperactivity between left and right subthalamic nucleus parallels severity of extremity symptoms in Parkinson's disease patients. Society for Neuroscience, New Orleans, 2003.

  26. Albea JR, Kao CC, Fatakia A, Jansen D, Mahadevan-Jansen A, Konrad PE. Optical stimulation of peripheral nerve. American Association of Neurological Surgeons Annual Meeting, 2003.

  27. Albea JR, Kao CC, Konrad PE. Simultaneous bilateral subthalamic DBS with parallel neurophysiologic localization data. American Association of Neurological Surgeons Annual Meeting, 2003.

  28. Kao CC, Charles D, Davis T, Fang J, Albea JR, Konrad PE. Asymmetry of overactivity between left and right subthalamic nucleus parallels severity of extremity symptoms in Parkinson's disease patients. 8th International Congress of Parkinson's Disease and Movement Disorders, Rome, 2004.

  29. Davis TL, Charles D, Kao CC, Fan J, Fenichel GM, Konrad PE. The anatomic specificity of rest tremor suppression. 8th International Congress of Parkinson's Disease and Movement Disorders, Rome, 2004.

  30. Cetinkaya E, D'Haese PF, Kao CC, Konrad PE, Fitzpatrick JM, Dawant BM. Method for identifying brain nuclei from micro-electrode signals. ASSFN Neuromodulation, Cleveland, 2004.

  31. Kao CC, Davis T, Charles D, Fang J, Albea J, Konrad PE. Correlating symptoms and neuronal activities- Bilateral simultaneous microrecordings from parkinson's and essential tremor patients. ASSFN Neuromodulation, Cleveland, 2004.

  32. D'Haese PF, Cetinkaya E, Kao CC, Konrad PE, Dawant BM. Creation and use of an atlas of optimal positions for the fully automatic selection of DBS target points. ASSFN Neuromodulation, Cleveland, 2004.

  33. D'Haese PF, Cetinkaya E, Kao CC, Konrad PE, Dawant BM. Deep brain electrophysiological atlas for deep brain stimulators (DBS) implantation. ASSFN Neuromodulation, Cleveland, 2004.

  34. Gajendiran M, Lima EA, Konrad P, Kao C, Faudenbacher FJ. High resolution multi-electrode mapping of thalamocortical oscillations in in-vitro rat brain slices during high frequency deep brain stimulation. ASSFN Neuromodulation, Cleveland, 2004.

  35. Wells J, Mariappan K, Albea J, Jansen ED, Konrad PE, Mahadevan-Jansen A, Kao CC. Optical stimulation of neural tissue. Society for Neuroscience, San Diego, 2004.

  36. D'Haese PF, Pallvaram S, Niermann K, Spooner J, Kao CC, Konrad PE, Dawant BM. Automatic selection of DBS target points using multiple electrophysiological atlases. Lecture Notes in Computer Science, MICCAI, 2005.

  37. Spooner J, D'Haese PF, Konrad PE, Dawant BM, Sun DA, Kao CC. Computer-generated selection of subthalamic nucleus targets for Deep Brain Stimulation: A case report. Congress of Neurological Surgeons Annual Meeting, Boston, 2005
    .
  38. Gajendiran M, Lima EA, Konrad PE, Kao CC, Baudenbacher FJ. Effects of low and high frequency thalamic stimulation on spontaneous cortical local field potentials of thalamocortical rat brain slices. Society for Neuroscience, Washington, DC, 2005.

  39. Spooner J, Yu H, D'Haese PF, Pallavaram S, Kao CC, Humbert G, Dawant B, Konrad PE. Fully-automated deep brain stimulation target selection better than traditional methods. AANS Annual Meeting, San Franscisco, 2006.

  40. Kao CC, Spooner J, Yu H, Davis T, Fang J, Hedera P, Cooper M, Charles PD, Konrad PE. Direct zona incerta stimulation produces efficacy in treating Parkinson's disease- an intraoperative study during the STN mapping. American Society for Stereotactic & Functional Neurosurgery Meeting, Boston, 2006, accepted.

  41. Kao CC, Spooner J, Yu H, Davis T, Fang J, Hedera P, Cooper M, Charles D, Konrad PE. Direct zona incerta stimulation produces efficacy in treating Parkinson's disease- an intraoperative study during the STN mapping. ASSFN, Boston, 2006.

  42. Spooner J, Yu H, D'Haese P, Pallavaram S, Kao CC, Humbert G, Dawant B, Konrad PE. Fully-automated Deep Brain Stimulation target selection better than traditional methods. AANS, San Francisco, 2006.

  43. Spooner J, Tatsas A, Abel T, Yu H, Kao CC, Konrad PE, Davis TL. Deep brain stimulation in white matter superior to STN is effective in Parkinson's disease: A 5-year postmortem analysis. American Society for Stereotactic & Function Neurosurgery Meeting, Boston, 2006, accepted.

  44. Konrad PE, Margolin L, Franklin R, Kao CC. Customized stereotactic system for research in animals: Advantages of a rapid-prototyped platform over traditional stereotactic frames. Society for Neuroscience annual meeting, Atlanta, 2006, accepted.

  45. Konrad PE, Kao CC, Franck JI, Spooner J, Yu H, Charles PD, Fang JY, Davis TL. Deep brain stimulating electrodes placed using a novel miniature steretotactic frame: Clinical experience from 144 patients. 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, 2006, accepted.

  46. Kao CC, Spooner J, Yu H, Charles PD, Davis TL, Fang JY, Konrad PE. Improved patient comfort and surgical efficiency using the Starfix Stereotaxy System in 106 patients undergoing DBS implantation. 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, 2006, accepted.

  47. Kao CC, Yu H, Spooner J, Hedera P, Konrad PE. Trainstimulation has identical efficacy as continuous stimulation in VIM DBS: A strategy to prolong battery life. 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, 2006.

  48. Konrad PE, Spooner J, Yu H, Hedera P, Kao CC. Improved energy efficiency in train versus continuous stimulation of STN for rigidity suppression in a PD patient. 10th International Congress of Parkinson's Disease and Movement Disorders, Kyoto, 2006, accepted.

  49. Feng H, Mathews G, Kao CC, MacDonald R. Seizure stage-dependent alterations of GABA receptor phasic inhibition and allosteric modulation during development of status epilepticus. Society for Neuroscience, Atlanta, 2006.

  50. Konrad PE, Margolin L, Franklin R, Kao CC. Intervene diseased human brain bilateral simultaneously: Microrecordings/DBS implantations using customized bilateral platform in DBS surgery. Society for Neuroscience, Atlanta, 2006.

  51. Harrison CH, Manus ND, Gill CE, Kao CC, Remple MS, Davis TL, Neimat JS, Konrad PE, Charles PD. Firing patters of STN in early stage PD patients implanted with DBS. Movement Disorders. 2007; 22(16): S10-11.

  52. Kao CC, Konrad PE, Wells J, Jansen ED, Mahadevan-Jansen A. Optical stimulation of heart pacemaking in rat. (Patent Filling.)

  53. Kao CC, Carron R, Benabid AL, Konrad PE. Recovering effects of thalamocortical stimulation on ischemia-induced inactivation of cortical oscillation in rat brain slices.

 

 

 

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